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02-02-2007, 03:02 AM
Cognitive Performance in Long-Term Abstinent Alcoholic Individuals
George Fein, Ph.D, Jennifer Torres, B.A., Leonard J. Price, Ph.D,
and Victoria Di Sclafani, M.P.H
Neurobehavioral Research, Inc., Corte Madera, CA
Alta Bates Medical Center, Herrick Campus, Berkeley, CA
Address reprint request and correspondence to:
Dr. George Fein
Neurobehavioral Research, Inc.
201 Tamal Vista Boulevard
Corte Madera, CA 94925
This work was supported by Grants AA11311 (GF) and AA13659 (GF), both from the
National Institute of Alcoholism and Alcohol Abuse.
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Page 2
Cognitive Performance in Long-Term Abstinent Alcoholics
Abstract
Background: There are few investigations of the potential recovery of neurocognitive function in chronic alcoholic samples after very long-term abstinence. The current study examined cognitive abilities in middle-aged, (mean age 46.8 years) long-term abstinent alcoholics (LTAA). Twenty-five LTAA men and 23 LTAA women abstinent for an average of 6.7 years were compared to an equal number of gender and age comparable
normal controls (NC). We examined the association of neurocognitive variables with age, duration of abstinence, alcohol use measures, and the density of family history of problem drinking.
Methods: LTAA and NC underwent comprehensive neuropsychological assessment. Performance was measured in the following nine domains: abstraction/cognitive flexibility, attention, auditory working memory, immediate memory, delayed memory, psychomotor function, reaction time, spatial processing, and verbal skills.
Results: LTAA performed similarly to NC, except for deficits in the spatial processing domain. The spatial processing results must be interpreted with caution because of multiple comparison issues; however, spatial processing deficits are among the impairments most often reported in abstinent alcoholics. None of the cognitive measures was associated with length of abstinence, any alcohol use variable, or family history measure.
Conclusions: Very long-term abstinence resolves most neurocognitive deficits associated with alcoholism, except for the suggestion of lingering deficits in spatial processing.
Keywords: Alcoholism; long-term abstinence; cognition; neuropsychology; aging
George Fein, Ph.D, Jennifer Torres, B.A., Leonard J. Price, Ph.D,
and Victoria Di Sclafani, M.P.H
Neurobehavioral Research, Inc., Corte Madera, CA
Alta Bates Medical Center, Herrick Campus, Berkeley, CA
Address reprint request and correspondence to:
Dr. George Fein
Neurobehavioral Research, Inc.
201 Tamal Vista Boulevard
Corte Madera, CA 94925
This work was supported by Grants AA11311 (GF) and AA13659 (GF), both from the
National Institute of Alcoholism and Alcohol Abuse.
________________________________________
Page 2
Cognitive Performance in Long-Term Abstinent Alcoholics
Abstract
Background: There are few investigations of the potential recovery of neurocognitive function in chronic alcoholic samples after very long-term abstinence. The current study examined cognitive abilities in middle-aged, (mean age 46.8 years) long-term abstinent alcoholics (LTAA). Twenty-five LTAA men and 23 LTAA women abstinent for an average of 6.7 years were compared to an equal number of gender and age comparable
normal controls (NC). We examined the association of neurocognitive variables with age, duration of abstinence, alcohol use measures, and the density of family history of problem drinking.
Methods: LTAA and NC underwent comprehensive neuropsychological assessment. Performance was measured in the following nine domains: abstraction/cognitive flexibility, attention, auditory working memory, immediate memory, delayed memory, psychomotor function, reaction time, spatial processing, and verbal skills.
Results: LTAA performed similarly to NC, except for deficits in the spatial processing domain. The spatial processing results must be interpreted with caution because of multiple comparison issues; however, spatial processing deficits are among the impairments most often reported in abstinent alcoholics. None of the cognitive measures was associated with length of abstinence, any alcohol use variable, or family history measure.
Conclusions: Very long-term abstinence resolves most neurocognitive deficits associated with alcoholism, except for the suggestion of lingering deficits in spatial processing.
Keywords: Alcoholism; long-term abstinence; cognition; neuropsychology; aging