Trazodone Addiction and Abuse


Trazodone Addiction and Abuse

Trazodone is also known as Trazodone HCI, and it is an anti-depressant medication that is chemically unrelated to other known antidepressant medications including Tricyclic and Tetracyclic medications.

It is known as a Triazolopyridine derivative, and it is an off-white or white power that is somewhat soluble in water.


Trazodone HCI is designated for oral administration and comes in several different dosages, including a 50 mg tablet, a 100 mg tablet or a 150 mg tablet depending on the dosage recommended by your physician. Additionally, each of the Trazodone HCI tablets also contains a number of inactive ingredients including Sodium Starch Glycolate, Microcrystalline Cellulose, Magnesium Stearate, Anhydrous Lactose and Colloidal Silicon Dioxide.

Trazodone is classified as a Serotonin uptake inhibitor as well as an anti-depressive agent. Trazodone falls into a class of medications that are known as Serotonin modulators, and what this means is that the drug's primary mechanism is to increase how much Serotonin is present in the brain. Serotonin is a natural brain substance that is responsible for maintaining mental balance, and so upping the amount of Serotonin in the brain can reverse feelings of depression.

Why is Trazodone Prescribed?

Through clinical trials, Trazodone has proven to be effective in treating a number of different depressive disorders, including major depressive disorders as well as other types of depressive disorders. For example, Trazodone has proven to be effective at treating insomnia and anxiety related disorders, and it is often recommended by physicians for treatment of these depressive disorders in individuals that are schizophrenic or schizoaffective, according to the AMA Drug Evaluations Annual in 1994.

Trazodone HCL or Trazodone Hydrocloride tablets have been indicated for treating a variety of different types of depression. The efficacy of this medication has been proven in outpatient and in-patient settings alike, and it has been used successfully in treating people with depression both when they also have prominent anxiety and when they do not.

This anti-depressive agent is most beneficial for people that experience major depressive episodes, and what this implies is that they have persistent and prominent dysphoric or depressed moods lasting at least two weeks and occurring nearly daily. This type of depressive mood is typically capable of interfering with the person's ability to function on a daily basis and is typically coupled with a number of specific symptoms including:

  • Changes in Sleep
  • Changes in Appetite
  • Psychomotor Retardation or Agitation
  • Loss of Interest
  • Decrease in Sexual Drive
  • Feelings of Worthlessness or Guilt
  • Increased Fatigue
  • Impaired Concentration
  • Slowed Thinking
  • Thoughts of Suicide

Statistics Relating To Trazodone

The most common complication associated with Trazodone abuse is actually death from overdose. Death from overdose of Trazodone typically occurs when Trazodone is consumed in higher-than-normal amounts while consuming other drugs concurrently. For example, combining alcohol abuse with Trazodone abuse is a common cause of overdose related death.

How is Trazodone Abused?

As an anti-depressant medication, the most common way that Trazodone is abused is by taking the medication in dosages higher than what is recommended by your physician. Another way that taking Trazodone can become abusive is when the medication is taken in any manner that goes against what was recommended by the physician and the information that comes with the prescription.

What Effects Does Trazodone Have on the Body?

Trazodone is absorbed into the body following oral administration, and it does not localize in any specific tissue of the body. If it is taken following food ingestion, then there may actually be an increase in how much of the drug is absorbed coupled with a decrease in the maximum concentration as well as a lengthening in the time necessary for maximum concentration. It may or may not be recommended that you take food when taking Trazodone.

The way that this medication actually works is by stimulating the amount of Serotonin in the brain, a natural substance responsible for promoting good feelings. Unfortunately, what this means is that people who are not getting the results that they seek may unfortunately attempt to up their dosage without consulting a physician in order to generate a better mood. This behavior is one that can quickly lead to addiction and abuse of the drug.

Trazodone Abuse Treatment Options

The first step to treatment of Trazodone addiction and abuse is to wean the patient off of the drug slowly. Stopping the drug cold turkey is not advisable because it can cause withdrawal symptoms that are just as disastrous as the symptoms of abuse or addiction. The patient should slowly reduce their usage of the medication in conjunction with behavioral therapy, because treating both the physical and mental aspects of the medication abuse is absolutely essential in ensuring that it is eliminated completely. A drug addiction rehabilitation center can closely monitor each patient in order to ensure their health and safety while they detox and work toward sobriety.

References
Medline Plus U.S. Food and Drug Administration

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