Club Drugs - An Examination of Ecstacy, GHB, LSD, Rohypnol, Methamphetamine and Ketamine

Club Drugs - An Examination of Ecstacy, GHB, LSD, Rohypnol, Methamphetamine and Ketamine

Club drugs have become the drugs of choice at all night dance parties. These dance parties are often referred to as raves or trances and are generally frequented by young adults. These dance parties are held at clubs, bars and hotels. These high energy parties frequently involve loud rock music and flashing neon or laser lights. These all night parties frequented by ravers are almost always associated with the use of club drugs.

The use of club drugs has increased significantly over the past 2 decades. The danger of mixing alcohol and club drugs also has the potential to cause serious intoxication and fatalities are not unheard of.

MDMA, GHB, Rohypnol, Ketamine, Methamphetamine, and LSD are the most common club drugs used at these parties. One reason for their increased use is the easy availability, low cost and their intoxicating effects produced. Because the majority of the club drugs are colorless, tasteless and odorless, they can easily be added inconspicuously to beverages by persons who want to intoxicate or sedate others individuals.

Because of the tendency of club drugs to sedate others, the subject of date rape has become a recent concern. Date rapes have been on the rise and often involve friends and associates. These drugs have the potential to cause retrograde amnesia and thus the victims usually are unable to remember or have any memory of the event. These drugs also have the ability to decrease a person’s inhibition and alter the mental capacity of individuals. These factors make it easy to date rape friends or acquaintances.

Due to the increased demands for these drugs and the potential to make money, many individuals intentionally manufacture them under less than ideal conditions. Thus possible contamination and impurities are always a concern for users.

MDMA (Ecstasy)

The most widely used club drug is MDMA (Ecstasy). MDMA was developed and marketed in the early 1990s as an appetite suppressant, although it has never been clinically used in humans. The drug bears a strong resemblance to amphetamine like drugs. When ingested, it can produce brain stimulation with a dominance of hallucinogens and psychedelic effects. Over the past decade the use of the drug has slightly declined among older individuals but the use of MDMA is still on the increase by teenagers and college students.

MDMA has dual properties acting as a brain stimulant and also has the ability to generate hallucinogenic effects. Ecstasy is an available as a pill/capsule which is easily concealed. Its duration of action is known to last at least 4-8 hours. In a few people it can cause idiosyncratic reactions like depression, insomnia and severe anxiety for long periods, ranging from a few days to weeks. Other common side effects of ecstasy include panic attacks, syncope, coma, seizures, chills, diaphoresis, muscle cramps and blurred vision. Deaths have been known to occur especially when the drug is combined with alcohol or other club drugs. MDMA is known to cause malignant hyperthermia which is fatal if not treated.

MDMA use enables the individual to be awake for extended periods, but this may lead to dehydration, heart or kidney failure due to lack of appetite and physical over activity. MDMA is neurotoxic agent and its affects to the brain are permanent if used chronically.

Gamma Hydroxyl Butyrate (GHB)

GHB (liquid ecstasy) is a strong sedative and often used as “date rape” drug. The drug is available as a clear liquid, powder, capsule or pill and is easily dissolved in alcohol or soft drinks. Once ingested, the drug rapidly takes effect and the sedative effects can last up to 4-6 hours. Prolonged loss of consciousness, breathing difficulties, seizures, coma and even death has been reported with the drug.

The drug is used predominantly by adolescents and young adults during all night parties. The drug is often manufactured at home by obtaining ingredients purchased from local food stores, pharmacies and the internet. The drug has the potential to be a strong sedative and also has euphoric effects. Also noticed over the past decade is that GHB can release anabolic hormones which can increase muscle size. Some claim that GHB is also a potent aphrodisiac like chemical.

Because GHB is a central nervous system depressant, it can also lead to increased lethargy, coma and even death. Overdose with GHB are not rare especially when it is ingested with alcohol or other CNS suppressant drugs. The drug is rapidly excreted from the body and often escapes detection in the body when patients are admitted to hospital.


Rohypnol (flunitrazepam) is also known as Rophies. It belongs to the benzodiazepine class of drugs (such as valium) and acts like a sedative. It is not approved for clinical use in the USA, but is approved as a sedative in Europe. Because of its ability to cause antegrade/retrograde amnesia, it is often used in anesthesia.

The drug is tasteless and odorless and is easily dissolved in both nonalcoholic and alcoholic beverages, thus making it a popular “date rape” drug. The drug is very potent and has a prolonged action which can last up to 12 hours. When combined with alcohol, it is known to cause mental confusion and lethargy. Drowsiness, dizziness, mental slowing lethargy and constipation can result with the use of rohypnol. Deaths have been reported with the drug when combined with alcohol.


Methamphetamine (speed) is a brain stimulant that causes delusions of grandeur, hyperexcitation, irritability, anxiety, and panic. The drug is frequently manufactured in clandestine factories using impure and cheap ingredients. The drug may be ingested, inhaled or even smoked. It is associated with a number of serious side effects which include mental confusion, extreme aggression, paranoia, psychotic ideations and damage to the heart. It has a great potential to be addictive. It is available as a pill, capsule or powder; the drug can be ingested, snorted, injected or smoked. Its actions may last up to 24 hours. When first ingested, it always produces an intense rush and a feeling of extreme confidence and euphoria.

Overdose with the drug can cause extreme agitation, slurred speech, fever, hallucinations, seizures and death. Methamphetamine is known to cause irreversible damage to the heart, kidney, lung and liver. When the drug is injected, the spread of HIV has been known to occur, especially in those sharing needles.


LSD (acid) is a chemical with hallucinogenic properties and has the ability to generate extra sensory perceptions. The effects of LSD are highly unpredictable. Different individuals experience different perceptions, depending on their pre morbid personality.

LSD is available as a clear liquid, tablet, capsule, or the drug may be leached on to pieces of paper which can be swallowed. The effects of LSD are apparent within 20-40 minutes after ingestion and can cause a mild increase in heart rate, blood pressure, diaphoresis and a loss of appetite. Dry mouth and restlessness are also common features.

Overdose can cause dramatic visual flashbacks, psychotic ideations and delusions of grandeur. Extrasensory perceptions such as sound and colors are amplified. Some individuals may experience severe reactions such as frightening vivid imaginations and this is referred to as a “bad trip”. Bad trip reactions can often last from 12-24 hours. Those who use LSD chronically are prone to developing psychotic ideations and recurrent hallucinations.


Ketamine is a general anesthetic used in clinical medicine. It is widely used in animal medicine also and has properties similar to the hallucinogen, Phencyclidine. The agent has the ability to cause dissociative anesthesia and is available as a liquid or powder.

After anesthesia with ketamine, patients have reported hallucinations and dream like states. Illicit use is common with this agent that can be inhaled, injected or even smoked with marijuana or cigarettes. The drug can increase blood pressure and may even cause difficulty in breathing. Deaths have been reported with this drug. Prolonged use of ketamine often leads to mental confusion, impaired learning and loss of memory.


Club drugs are illegal drugs which are widely used at all night parties. Almost all of them have the potential to cause serious health problems and death is always a concern. The drugs have the potential to cause addiction with serious consequences. Club drugs are frequently used as “date rape" drugs and thus all friends' acquaintances and associates “beware”.


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  5. Klein-Schwartz W. Abuse and toxicity of methylphenidate. Curr Opin Pediatr. Apr 2002; 14(2):219-23.
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Topic Discussion

  1. Addict

    Funny...I was actually writing an essay for English, and I wanted to find drugs that could cause retrograde amnesia. This should help, since I also need a hallucinogen. :)

  2. Addict

    This article is quite slanted, and not well researched. The article lists the negative effects of drugs, but does not address their popularity at rave clubs. Is the author naive enough to think people use these drugs for their negative effects? Other things are just flat out wrong, for instance, no one swallows LSD - the blotter is held against the gums or tongue for several minutes and the drug enters the body by absorption through the skin. The author also fails to indicate what levels of each drug could result in an overdose.

    • Addict

      You, my friend are the one that needs to do much more research. As we speak, my 28 year old son is in the hospital for this very reason. He was given a hit of blotter...told to swallow it...which he did. Later that evening he had a few beers, the combination has him in I.C.U. in a Philadelphia hospital with spiking, out of control blood pressure (even though he is currently on meds to control this). He was a straight A student, mellow, happy go lucky, likable guy...and seems...we may be looking at his future. He does not recognize me, his mother, and his girlfriend of 3 years and has no idea what the food is that sits directly in front of him. He does not eat; he cannot answer a question or even ask one. He has been in this state for over a week now, remaining in I.C.U. for the duration. This is's what you do...the people who are out there telling you in blogs about their highs and how great this drug is or how terrible that drug is....are probably telling the truth. Not that anyone should use that info to go get high...but perhaps begin to understand the ability of the drug to change ones personality, traits, physical well-being and if you look at my beautiful and were lucky enough to have known him before....realize...that it and it alone has destroyed his future, my future...Our lives.

      • Addict

        Yes this is correct and true! It happens all the time!!!

  3. Addict

    I've used LSD on many occasions as a youngster and found it a wonderful escape! However my sister and a couple of others have never been the same since! They will never recover and some have died.

    It depends on the individual but is very risky for some. Please bear this in mind. Again I thought it great! Too many people mentally gone and death ensued - DON'T DO IT!

  4. Addict

    Thanks for writing this in a way that a 14 year old (me) can understand it. I needed to get information for a paper I'm writing for health class. If it weren't for you, I would have like nothing, just kidding. I had a page and a half already, I just needed another page. Your article helped. Don't hate on me for writing this either. Peace!

  5. Addict

    Is there a drug or perhaps one of the drugs mentioned that can absorb into the skin? Im asking for myself... I was at a club years ago and remembering a man asking to dance with me. Seconds later my butt was soaked and he was grabbing it ( down my pants)Im remembering because I was telling him dont, im all soaked from being sweaty dancing. . About 5 minutes after that I had started feeling dizzy. Reading this today gave me flashbacks (kinda freaking out right now) . Anyways, I could barely walk to my car. ( had only 2 drinks literally) . And dont remember anything after that. I think I woke up in my car and the parking lot was empty. So im not sure .... I was maybe..21 22 years old. Now I am 30.

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