Zydone Addiction - A Mixture of Hydrocodone and Acetaminophen

Zydone Addiction - A Mixture of Hydrocodone and Acetaminophen

What is Zydone?

Zydone is a mixture of hydrocodone and acetaminophen (or Tylenol). Zydone is sold under many different names including: Allay and Anexsia

Zydone is an opiate which works as such an effective painkiller because it combines these two medications.

Acetaminophen works by blocking the production of prostaglandins by the body. Hydrocodone attaches to the opiate or pain receptors in the brain and causes feelings of pleasure and euphoria.

How is Zydone Prescribed?

Zydone can be obtained in capsule, liquid form and tablets. Zydone is usually taken every four to six hours by mouth. Zydone should only be used when prescribed by a doctor.

What are Side Effects of Zydone Use?

The most common side effects of Zydone use include:

  • Light-headedness
  • Dizziness and sedation
  • Nausea and vomiting

Side effects of Zydone use by body system include:
  1. Central Nervous System:
    • Drowsiness
    • Mental clouding
    • Impairment of mental and physical performance
    • Fear
    • Psychic dependence
    • Mood Changes
  2. Gastrointestinal System (stomach):
    • Constipation
  3. Genitourinary System:
    • Urinary retention
    • Spasms of the ureters
  4. Respiratory System:
    • Depression of the respiratory center:
  5. Especially in the case of overdose in which case respiratory depression can lead to death.

  6. Dermatological System:
    • Scratching
    • Itchiness
  7. Blood Disorders:
    • Allergic reactions
    • Rash
    • Thrombocytopenia (blood does not clot effectively and can lead to bleeding)
    • Agranulocytosis (a decrease in white blood cells run the immune system)

Other Side Effects:

There have been cases of hearing impairment or complete hearing loss. This however, is usually found in inpiduals who have overdosed.

What are the dangers of Acetaminophen in Zydone?

Anything that one consumes is processed by the liver. Medications are no different. Acetaminophen is especially hepatotoxic or harmful to the liver. This is why an inpidual taking a drug with acetaminophen may see a yellowing of the skin or jaundice after prolonged use.

A reduction of white blood cells or agranulocytosis as mentioned above is also due to liver damage as is itching or increased bleeding time. The liver is responsible for creating what are called clotting factors. Itching occurs because since the liver cannot process substances properly bile salts which are usually contained in the liver are released through the skin causing dry and pruritus (which is itching).

What are the Signs of Zydone Overdose?

As with all drug use there is always the chance for addiction both physiological and psychological as well as overdose. Since Zydone is a mixture of Hydrocodone and Acetaminophen all the risks associated with opiate use apply to Zydone. The specific signs that an inpidual is experiencing an overdose include:

  • Extreme drowsiness
  • Pinpoint pupils
  • Nausea
  • Sweating
  • Vomiting
  • Blue lips
  • Dark urine
  • Jaundice (yellowing of the skin or eyes)
  • Confusion
  • Weak pulse
  • Cold and clammy skin
  • Muscle weakness
  • Fainting
  • Slow heart rate
  • Coma
  • Shallow breathing
  • No breathing

What are Treatment Methods for Zydone?

There are many different ways in which Zydone detoxification can occur. Treatment medications are often used in order to block the withdrawal symptoms of the drugs. Medications can also be used in order stop drug cravings related to opioid addiction. The current medication used is methadone which at a satisfactory level when combined with behavioral therapy can help to reduce death rates as well as diminishing the many health complications associated with Zydone abuse.

Behavioral therapy which focuses on changing thought processes of drug users thereby changing behaviors is very effective with drug treatment. Behavioral therapies include:

  • Counseling
  • Psychotherapy
  • Support groups
  • Family therapy

These treatments help provide long term abstinence from drug abuse especially when used in combination with medications. Zydone addiction is quite treatable so if you or someone you know is having a problem with Zydone or any other type of Hydrocodone derivative seeking treatment can and will help.

Anderson PO, Sauberan JB, Lane JR, Rossi SS. (2007). Hydrocodone excretion into breast milk: the first two reported cases. Breastfeed Med. Mar;2(1):10-4.
Johnson, P. A. Editor. “Opioids” Encyclopedia of Cancer.
Oh, A.K., Ishiyama, A. and Baloh, R. W. (2000). Deafness associated with abuse of hydrocodone/acetaminophen. Neurology, Vol. 54, Issue 12, 2345
Rodriguez RF, Castillo JM, Del Pilar Castillo M, Nunez PD, Rodriguez MF, Restrepo JM, Rodriguez JM, Ortiz Y, Angel AM. (2007). Codeine/acetaminophen and hydrocodone/acetaminophen combination tablets for the management of chronic cancer pain in adults: a 23-day, prospective, double-blind, randomized, parallel-group study.
Clinical Therapy. Apr;29(4):581-7.

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